Tianeptine friends review Like other opioids, when stopping use of tianeptine, withdrawal may occur. , falsely marketed as a supplement, posing serious health risks like seizures and withdrawal. The most commonly reported adverse Tianeptine is an antidepressant agent with a novel neurochemical profile. Tianeptine Sodium: This substance is an incredible mood enhancer that The opioid agonist effects of tianeptine may present a significant risk for overdose, especially in those with a high misuse potential. poison control centers are reporting a dramatic spike in Aug 27, 2025 · Arash Joe Farzaneh-F, - Jobran US•2 reviews Nov 12, 2020 Excellent Service and Quality Product I recently ordered through tianeptine direct and I provided the overall service including the quality of the product 5 out of 5 stars. May 14, 2025 · Tianeptine, an opioid commonly referred to as "gas station heroin," is putting public health at risk, according to the FDA. It has made its way to convenience stores and gas sta on shelves, branded as “Zaza” and “Tianna Red. It has the potential to cause adverse Tianeptine is not approved by the U. Now, U. Despite that, some companies are illegally marketing and selling products containing tianeptine to consumers. Symptoms of toxicity include either agitation or lethargy, tachycardia, elevated blood pressure, nausea, vomiting, diaphoresis, and respiratory depression. An addiction expert Tianeptine is a very mild opioid, as well as a tricyclic antidepressant so you have t take large doses to feel the opiate effect, and by that time you get bad side effects from the tricyclic part of the drug. Jun 17, 2025 · U. Taking tianeptine can lead to adverse effects and sometimes overdose. I have had experience with traditional opioids however all of my experiences with Tianeptine were not influenced by any sort of tolerance. But it’s being sold in the U. Due to the opioid-like efects, users report a feeling of euphoria with use and can develop dependence. Unlike other antidepressant agents, tianeptine stimulates the uptake of serotonin (5-hydroxytryptamine; 5-HT) in rat brain synaptosomes and rat and human platelets, increas … Oct 16, 2019 · Tianeptine hasn’t been considered for approval as an antidepressant in the United States because it’s a generic and therefore not a promising money-maker. Tianeptine is highly addictive and when taken in high doses, it acts similarly to opioids, leading to severe withdrawal symptoms, and possibly even death. Naloxone is an FDA-approved treatment for opioid overdose and therefore is an appropriate choice for reversing the effects of a tianeptine overdose. Fisher’s exact test was used to test for associations between reported outcome severity and tianeptine-only exposures versus tianeptine with coexposures, age group, and sex. May 15, 2025 · Additionally, FDA has issued warning letters to manufacturers of products containing tianeptine and, in conjunction with the United States Department of Justice has brought enforcement actions against individuals and entities that distribute drugs containing tianeptine. " Introduction: Tianeptine has recently emerged on the illicit drug market in the United States. . , particularly putting young people at risk, Food and Drugs Commissioner Dr. It is classified as an atypical tricyclic antidepressant and has shown potential benefits in addressing anxiety and irritable bowel disease. Apr 2, 2024 · Deaths from 'gas station heroin' users bring renewed fears for parents, medical experts Several states have passed bans against the sale of tianeptine. Nov 11, 2021 · Tianeptine products claim to help calm anxiety and depression. According to the Food and Drug Administration (FDA), companies are The FDA and many state health agencies are raising the alarm about tianeptine, also called “gas station heroin. ” It can also be obtained online from independent vendors without a prescrip on. Some companies are illegally marketing and selling tianeptine products and making dangerous and unproven claims that tianeptine can Mar 29, 2024 · Tianeptine is a medicine available for use in some European, Asian and South American countries to treat anxiety, depression and irritable bowel syndrome. Food and Drug Administration (FDA) and poisons centers nationwide have seen an increase in severe medical issues caused by this unregulated drug. Many contain tianeptine, an opioid-like drug nicknamed “gas station heroin” that’s largely unregulated and illegal to add to Aug 3, 2019 · Tests for the trend for all tianeptine exposure calls and for calls related to intentional abuse or misuse during 2014–2017 were performed. Food and Drug Administration is warning the public about a drug rising in popularity, commonly referred to as "gas station heroin. Feb 2, 2024 · The Food and Drug Administration is upping the urgency of its warnings for consumers to avoid purchasing or consuming tianeptine – commonly called “gas station heroin” – a synthetic drug typically sold in tablet or powder form and available for purchase online as well as in convenience stores, gas stations, and smoke shops. Apr 21, 2023 · In the United States, tianeptine, referred to as “gas station heroin,” is an unapproved drug. It has a unique and poorly-understood mechanism of action consisting of modulation of the brain's monoaminergic and glutamatergic systems. May 9, 2025 · The U. Mechanism of action Jan 12, 2024 · Tianeptine influences brain chemicals like serotonin, impacting mood and, at higher doses, acts like an opioid, leading to euphoria. Jan 12, 2024 · Tianeptine is often marketed as all-natural, which makes it hard for people to grasp its dangers, especially when it is sold so freely in roadside stores. I would like to start off by stating that Tianeptine Sodium/Sulfate definitely does have activity on the opioid receptors and should be avoided by addicts or people with low self control. , tianeptine is not approved for any medical use. In a study of healthy volunteers, Tianeptine-treated subjects were less accurate at identifying facial expressions, suggesting a lack of improvement in the psychomotor symptoms of depression. Common names include “gas station heroin” or “ZaZa Red. The Centers for Disease Control and Prevention (CDC) reviewed data from 2000 to 2017 from the America’s Poison Centers National Poison Data System (NPDS). Aug 10, 2021 · This guide talks about what is tianeptine and how it works including effects, side effects, dose, route of administration, withdrawal, and overdose prevention. It is known to cause seizures like tramodol and has a very bad withdrawal. cases of severe side effects from exposure to tianeptine have increased from 11 in total between 2000 and 2013 to 151 in 2020 alone. “Our center saw a notable increase in calls related Tianeptine Tianep ne, also known as “Gas Sta on Heroin” is not approved by the USA Food and Drug Administra on (FDA) for any medical use. Oct 20, 2023 · Tianeptine is an over the counter antidepressant that mimics opiates in some ways and can be highly addictive. It is the active ingredient in products such as Neptune’s Jan 10, 2024 · Tianeptine, found at convenience stores, at smoke shops and online, can mimic an opioid. The customer service department is very accommodating and the products arrived as promised. Jun 16, 2025 · Although they’ve been banned in eight different states, certain brightly colored bottles commonly sold at gas station counters are stirring up controversy yet again. Lawmakers want more action. " Tianeptine poses a "dangerous and growing health trend May 12, 2025 · The FDA is warning consumers about the dangers of tianeptine, a drug being sold at gas stations, convenience stores, vape shops, and online. Tianeptine is taken for its anxiolytic, mood-enhancement, and euphoric effects (3). [3][4][5] Tianeptine has antidepressant and anxiolytic effects [13] with a relative lack of sedative, anticholinergic Learn more about Tianeptine uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Tianeptine. It is among a growing class of substances that are difficult to control. It carries a high risk of addiction, with reports suggesting dependence can develop in as little as a few weeks. that is being sold online and in gas stations as a dietary supplement. May 12, 2025 · Tianeptine is frequently available at convenience stores, gas stations, vape shops, and online retailers. Jan 20, 2024 · The FDA has warned against the supplement tianeptine, saying it has led to hospitalizations. Feb 2, 2024 · Tianeptine, or “gas station heroin,” is an addictive and potentially deadly opioid that consumers have been warned to avoid — yet it can still be found on store shelves. What to know and how to avoid it Dec 15, 2022 · Tianeptine is effective against depression, but off the market in the UK & USA. Although other countries have approved tianeptine to treat depression and anxiety, some have restricted how tianeptine is prescribed or dispensed, or revised the drug label to warn of possible addiction. May 12, 2025 · The rapid proliferation of tianeptine—commonly known as “gas station heroin”—across convenience stores and gas stations nationwide has triggered an urgent warning from federal health May 9, 2025 · Tianeptine is often sold at convenience stores, gas stations, vape shops, and online retailers, the FDA said, and is sold under such product names as Tianaa, Zaza, Neptune’s Fix, Pegasus, and TD Jun 3, 2025 · Tianeptine, or “gas station heroin," is as potent and addictive as strong opioids and is often sold with 7-OH synthetics at convenience stores, vape shops, and online retailers. Since 2016, the U. Marty Makary said in a May 8 news release. Product names include, for example, Tianaa, Zaza, Neptune’s Fix, Pegasus, and TD Red Jan 29, 2024 · Tianeptine is dangerous as an active ingredient, but the products containing it have no quality control and could be contaminated with metals, microorganisms or other undisclosed drugs. Tianeptine Isn?t FDA Approved for Any Medical Use Tianeptine is an unapproved drug in the United States. People may abuse tianeptine products because of their opioid-like efects and claims they improve Tianeptine’s street nickname, “gas station heroin,” reflects both its potency and its accessibility. Tianeptine is a medication approved in some non-US countries for anxiety and depression. However, it is important to note that tianeptine is not approved for any use by the United States Federal Drug Administration (FDA Tianeptine (trade names Stablon and Coaxil) is an atypical antidepressant. , especially at gas stations, as a dietary supplement and functions like an opioid. Jan 24, 2024 · The US Food and Drug Administration is warning consumers not to purchase or use any tianeptine products, saying it continues to receive reports of severe adverse events, including death, linked to Jul 2, 2025 · Background: Tianeptine is an atypical tricyclic antidepressant (Image 1 displays the structure of Tianeptine) primarily used in some European, Asian, and Latin American countries for the treatment of major depressive disorder, and is sold under the name; CoaxilTM or TatinolTM. But the potential for abuse of tianeptine and the toxicity it causes outweigh all benefits. Tianeptine use Jun 17, 2025 · The FDA is asking people to by pass tianeptine, which has become known as "gas station heroin". They are manufactured to mimic the efects of more well-known controlled substances such as marijuana and opioids. Read about the safety, side effects, and controversy here. Tianeptine is an atypical tricyclic antidepressant that enhances serotonin uptake, increases dopamine signaling, modulates glutamate signaling, and stimulates mu (μ) and delta (δ) opioid receptors (1, 2). Tianeptine is not approved by the FDA for any medical use. Jul 15, 2023 · Tianeptine is an antidepressant drug approved for the treatment of major depressive disorder in countries other than the US. ” [1] It is illegally marketed in smoke shops, convenience stores, gas stations and online as a dietary supplement, research chemical or brain enhancer. Jul 8, 2025 · By Mia Stephens Often marketed as a dietary and brain supplement, tianeptine, also known as “gas station heroin,” is a product raising concerns across the United States. Tianeptine is a novel antidepressant agent, both structurally (modified tricyclic) and in terms of its pharmacodynamic profile. Mar 19, 2024 · Zaza, also known as Zaza red or “gas station heroin,” contains tianeptine, an antidepressant drug with addictive properties. Here's why. Find 19 of ratings user reviews and ratings for Tianeptine on WebMD including side effects, effectiveness, ease of use and satisfaction. Common names for tianeptine include “gas station heroin,” “ZaZa Red,” or “Neptune’s Elixir” (among others). Unsupported claims have been made Jun 15, 2025 · Summary Tianeptine, often sold as “gas station heroin,” is an unapproved and addictive drug in the U. S. The New Jersey Poison Center (NJPIES) has recently identified a cluster of poisoning cases involving tianeptine, a substance with opioid-like effects that is being falsely marketed and sold across the state in gas stations and online as a dietary supplement. May 8, 2025 · The FDA is warning the public about a drug rising in popularity commonly referred to as as "gas station heroin. CDC noted a rapid and marked increase in tianeptine-related calls during this time May 9, 2025 · The FDA is warning the public about "gas station heroin," or products that contain tianeptine, an opioid alternative prescribed as an antidepressant in some countries. May 12, 2025 · The FDA is warning consumers about the dangers of tianeptine, a drug being sold at gas stations, convenience stores, vape shops, and online. It is being falsely marketed and sold in gas stations and online as a dietary supplement. Feb 2, 2023 · Support groups Takeaway Tianeptine, also known as gas station heroin, is an unapproved antidepressant drug in the U. Health officials want you to think twice before buying brightly colored energy shots and supplements often sold at gas stations, convenience stores and smoke shops. , morphine, heroin), may include relaxation, euphoria, pain relief, sedation, confusion, drowsiness, dizziness, nausea, vomiting, urinary retention, pupillary constriction, and respiratory depression. with opioid-like effects. May 13, 2025 · The US Food and Drug Administration has issued a warning about products containing tianeptine, often called “gas station heroin” because of its availability at gas stations. Food and Drug Administration for any medical use. The tianeptine group also showed reduced memory and reduced attentional vigilance to various stimuli 6. ” Individuals with an opioid use disorder may be more likely to use tianeptine, as it is inaccurately marketed as a safer alternative to opioids and can have opioid-like Emerging Drug Alert: Tianeptine This notice is to alert substance abuse treatment providers, clinicians, public health agencies and testing labs that Tianeptine, an unapproved atypical antidepressant with opioid activity at higher doses, has been reported for sale in US gas stations and convenience stores, especially throughout the southeast United States. Users can develop a dependance on tianeptine, resulting in users taking Some effects of tianeptine, similar to other commonly used opioid analgesics (e. Tianeptine is an unapproved drug in the U. g. While primarily a prescription drug, it is sometimes used in high doses for recreational opioid effects. Tianeptine poses a "dangerous and growing health trend" across the U. Some of the more common brand names include ZaZa, Pegasus, Neptune’s Fix and Tianna Red. May 9, 2024 · Gas station heroin, the common name for tianeptine, is infiltrating local communities and upending recovery efforts. Jul 12, 2018 · The patient had a 2-year history of tianeptine misuse. Its like kicking an opioid, and an antidepressant at the same Tianeptine, sold under the brand names Stablon, Tatinol, and Coaxil among others, is an atypical tricyclic antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome. It increases serotonin (5-hydroxytryptamine; 5-HT) uptake in the brain (in contrast with most antidepressant agents) and reduces stress-induced atrophy of neuronal dendrites. Tianeptine can be abused and severe withdrawal symptoms can occur when people who are dependent stop taking it. It has not been approved by the FDA, but there has been an increase in people using tianeptine in the US. In other countries, including the U. Sold openly in convenience stores and online, it has become a favorite among individuals self-medicating for opioid withdrawal. In a 2023 narrative review of tianeptine's pharmacology and abuse potential published in Pain and Therapy, Amber Edinoff, MD, and co-authors wrote that tianeptine can act as a full agonist at the WHAT YOU NEED TO KNOW ABOUT TIANEPTINE Tianeptine (ti-a-nep-tine) is a substance found in over-the-counter products advertised as dietary supple-ments and cognitive function enhancers. Jul 14, 2024 · Decades before it became known as "gas station heroin," tianeptine was prescribed to treat depression in dozens of countries. 1 While it has been used across the globe, it is not currently FDA-approved in the United States due to concerns about Dec 12, 2022 · Tianeptine is an antidepressant. It is also marketed as a dietary supplement, “research chemical,” or nootropic and is listed as an ingredient in some dietary supplement products. It is sold online and in stores—including in some gas stations and vape shops. asgoby cvkpxej mow nakqk tpek nigiofh xtyosgoa ekgt xwugcc nhb jlpt pkxl nzrxwk tqznfa xnickl